Food for special medical purposes, intended for the dietary treatment of drug-resistant epilepsies .
The microbiota controls the metabolism of Tryptophan (TRP) : an altered microbiota has been reported in epileptic patients, caused by a deficiency of TRP. Therefore, restoring a correct microbiota allows not only to increase plasma TRP but also to restore its correct metabolism and its cerebral uptake, in order to favor correct production of serotonin .
Confirming the role of serotonin, A reduced ability to obtain TRP from the diet has been reported in epileptic patients (nutritional vulnerability), which may also depend on its altered metabolism with a greater production of indole catabolites, which carry out reinforcing actions on the intestinal membrane. In particular, a reduction of one third in the rate of brain serotonin synthesis compared to controls has been estimated in epileptic patients.
In the 1990s we witnessed the reversal of the role of serotonin in epilepsy: mistakenly believed to be pro-convulsant, it was found to be anti-convulsant.
Given that serotonin is synthesized starting from TRP, an essential amino acid (which derives only from the diet), which competes with the other Large Neutral Amino Acids (LNAAs) both for cerebral uptake and for intestinal absorption, nutritional strategies are useful aimed at increasing both plasma TRP and its cerebral uptake.
Oral intakes of the serum protein alpha-lactalbumin were found to be capable of increasing the plasma TRP/LNAAs ratio, but, in the presence of an altered metabolism of TRP, this increase does not automatically correspond to an increase in its cerebral uptake (less than 1% of the TRP plasma is available for cerebral uptake) and therefore to an increase in cerebral synthesis of serotonin.
Thanks to its specific actions on the digestive system, alpha-lactalbumin she turned out to be capable of both modify the microbiota both of also increase the rate of synthesis of brain serotonin fivefold . Alpha-lactalbumin it was also found capable of increasing the neuropeptide Y , which has been defined to be a powerful endogenous anticonvulsant.
Furthermore, nourishing the cells of the digestive system well facilitates their response to the stimulation of alpha-lactalbumin. The specific nutrients of these cells are i short chain fats (Short Chain Fatty Acids, SCFAs) which carry out an anti-inflammatory action , are able to improve the metabolism of the precursors of tryptophan and serotonin and regulate the functionality of the intestine-brain axis at 360 degrees. Butyric acid , one of the most widespread SCFAs, contributes to the correct functioning of the intestinal mucosa , positively influences the ecosystem of the gastro-intestinal tract and has been proven to have anticonvulsant effects in various experimental models of epilepsy, positively influencing both the frequency of the crises themselves that aspects related to neuropsychiatric disorders .
The patented synergistic association between alpha-lactalbumin and butyric acid led to the development of Lalbaay, the first food for special medical purposes studied in Italy by reference centers in the field of epilepsy, to provide an effective and useful tool for the dietary management of drug-resistant epilepsies.
Promote correct production of serotonin
Lalbaay promotes the restoration of the gut microbiota, improving tryptophan (TRP) metabolism and increasing brain serotonin production, which is particularly beneficial for patients with drug-resistant epilepsies, who often have difficulty synthesizing serotonin from TRP.
Control of Epileptic Seizures
Thanks to the presence of alpha-lactalbumin, Lalbaay not only improves the plasma TRP/LNAAs ratio, but also increases the rate of brain serotonin synthesis up to five times. Furthermore, the increase in neuropeptide Y, a powerful endogenous anticonvulsant, further contributes to the control of epileptic seizures.
Anticonvulsant effects
Lalbaay combines alpha-lactalbumin and butyric acid to nourish digestive cells and optimize the metabolism of tryptophan and serotonin precursors. This leads to anti-inflammatory benefits, resulting in a reduction in seizures and improvements in neuropsychiatric disorders.
Alpha-lactalbumin
Alpha-lactalbumin
The bioavailability of alpha-lactalbumin is maximum: the entire dose taken orally is rapidly broken down into peptides, which are completely absorbed by the gastrointestinal system. Alpha-lactalbumin is the whey protein most present in milk, especially human milk. In fact, in our colostrum it represents as much as 40% of the proteins. Alpha-lactalbumin is the protein that Nature chose for man. Its actions at the intestinal level are fundamental for the brain development of the newborn. A peculiar characteristic of this protein is its high content of tryptophan, the only precursor of serotonin on whose availability brain development depends. In fact, a very recent study on animals demonstrates that repeated daily oral intakes of alpha-lactalbumin are able to increase the brain synthesis of serotonin; acting, therefore, in an absolutely natural way and without any side effects, just as Nature has prepared. Many neurological symptoms are due to brain serotonin deficiency.
Fructo-oligosaccharides (FOS) and Inulin
Fructo-oligosaccharides (FOS) and Inulin
They constitute the precursor of the main nutrient of intestinal cells: short-chain fatty acids. Therefore they nourish the cell, allowing it to respond better to the stimulation of alpha-lactalbumin which is useful for supporting the growth and development of correct intestinal flora.
Sodium Butyrate
Sodium Butyrate
Sodium butyrate (NaBu) is the sodium salt of butyric acid, a short chain fatty acid (SCFAs: Short Chan Fatty Acids: butyric, acetic, propionic and valeric acid) composed of four carbon atoms. Butyric acid is a natural byproduct of the fermentation of dietary fiber in the large intestine; it is the main source of energy for mucosal cells; stimulates their turnover and physiological maturation and plays a key role in maintaining the integrity of the mucosa and in the repair processes of intestinal lesions; stimulates the reabsorption of water and sodium in the colon; it contributes to lowering the intestinal pH, creating an unfavorable environment for the development of pathogenic bacteria. The correct quantity of butyric acid is therefore necessary for the metabolic health of the colon mucosa and more generally of the entire organism.
Instructions for use
Instructions for use
To be used under medical supervision. Recommended dosage: one sachet and two tablets twice a day, or according to the doctor's advice, preferably twelve hours apart. Take orally. The sachet (component A) dissolved in 150 ml of water at room temperature and the tablets (component B) must be administered at the same time, on an empty stomach (at least 15 minutes before meals).
Product notified to the Min.Sal. pursuant to Presidential Decree 57 of 03/20/02
Ingredients
Ingredients
Warnings
Warnings
Does not contain gluten. Contains milk derivatives.
storage
storage
Store in a cool (<25°C) and dry place, away from sources of light and heat.
Format
Format
Box containing 60 sachets (Alpha-lactalbumin, sodium butyrate, FOS and inulin).